Defamiliarization is a linguistic technique in which the speaker or writer tries to deviate from the standard language, which results in engaging the audience with some mental exploration, and thus provides the condition for a better understanding of the message to the extent that the effect will become much more significant than when using normal language. The Holy Qurʾan as a superhuman text has best used defamilairization in numerous instances and because of the importance of analyzing this technique in understanding one of the aspects of the miracle of the Qurʾan, this descriptive-analytical research, focusing on simile and allusion, attempts to scrutinize defamiliarization of substitution in the Qurʾanic ayahs related to the story of Prophet Noah (AS). The findings show that this technique has been effectively employed in the story of Prophet Noah in order to, among others, create exaggeration in the meaning and concept of ayahs, generalize the implications of ayahs, create excitement in the audience, generating mental exploration in them, and expand meanings and concepts of ayahs.